Substitution of Maloprim for dapsone.

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Agranulocytosis during malaria prophylaxis with Maloprim (pyrimethamine and dapsone).

A case of agranulocytosis during malaria prophylaxis with Maloprim (pyrimethamine and dapsone) is described. At the recommended dose of one tablet weekly this is apparently a rare occurrence but highlights one of the hazards in a changing climate of malarial prophylaxis in which the use of Maloprim is increasing.

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INTRODUCTION We report 3 cases of dapsone hypersensitivity syndrome due to anti-malarial chemoprophylactic treatment with maloprim, in military servicemen, presenting like a viral exanthem. CLINICAL PICTURE Three male military recruits presented with fever and rash, 6 to 8 weeks after commencing on weekly doses of maloprim. TREATMENT A course of topical and systemic corticosteroids and oral...

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Estimate of Armington substitution elasticity for fishery products in Iran

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INTRODUCTION A 22-year-old Malay soldier developed dapsone hypersensitivity syndrome 12 weeks after taking maloprim (dapsone 100 mg/pyrimethamine 12.5 mg) for anti-malarial prophylaxis. CLINICAL PICTURE He presented with fever, rash, lymphadenopathy and multiple-organ involvement including serositis, hepatitis and thyroiditis. Subsequently, he developed congestive heart failure with a reducti...

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ژورنال

عنوان ژورنال: BMJ

سال: 1983

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.287.6402.1379-c